Biosensors for Detection of Hepatitis B Virus: Review

Author:

Esfandiari Amir Hossein1,Hajipir Farkhani Hadis1,Hashemi Javan Zahra2,Vojdani Arastoo1,Velayati Mahla3,Mahaki Hanie4,Meshkat Zahra5,Manoochehri Hamed6,Avan Amir378,Tanzadehpanah Hamid53

Affiliation:

1. Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2. Department of Paramedical Sciences, Islamic Azad University of Mashhad

3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4. Vascular and Endovascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

5. Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

6. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

7. College of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq

8. Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia

Abstract

Abstract:: Hepatitis B is still one of the most important infectious diseases among humans, which is considered a serious threat to their lives. Early diagnosis of this disease can be an effective measure in stopping the chain of transmission and treatment of the disease. In this review study, an attempt has been made to explain the use of biosensors as a fast, high-efficiency, and low-cost method in diagnosis. The biosensors prepared for hepatitis detection included DNA-based, aptamers-based, protein-based, enzyme-based, antibody-based, and polymers-based biosensors, each of which had different advantages. The results of this review showed that almost all introduced biosensors had an acceptable performance. However, we suggest that aptamers are desirable for biosensing applications because they can change their structure to properly bind to their target, are cost-effective to prepare, and are highly sensitive.

Publisher

Bentham Science Publishers Ltd.

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