Affiliation:
1. School of Life Sciences, Henan University, Kaifeng 475004, China
Abstract
Abstract:
The antibacterial and antiviral functions of human defensin 5 lay the foundation for its
role as a core host protective component. In addition, HD5 also has the function of inhibiting tumor
proliferation and immune regulation. However, everything has two sides; cytotoxic and proinflammatory
properties may exist, while HD5 performs physiological functions. Accordingly, the
modification and engineering of HD5 are particularly important. Therefore, this review summarizes
the role of HD5 in various aspects of host defense, as well as modification of HD5 to ameliorate
the biological activity, with a view to promoting the clinical use of HD5.
Funder
Henan Provincial Department of Education, China
Publisher
Bentham Science Publishers Ltd.
Subject
Biochemistry,General Medicine,Structural Biology