Metabolites Study of Experimental Plant Derived Alkaloids: A Review

Author:

Manna Kuntal1ORCID,Somraj Singh Waikhom12ORCID,Goswami Sanchari13ORCID,Ashif Ikbal Abu Md1ORCID,Rajkhowa Amlanjyoti1ORCID,Debnath Bikash14ORCID

Affiliation:

1. Natural Cum Advance Synthetic Lab, Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Agartala, 799 022, India

2. Department of Allied Health Sciences, The ICFAI University, Kamalghat, Mohanpur, Agartala, 799 210, India

3. Department of Pharmacology, Bharat Institute of Technology, Mangalpally (V), Ibrahimpatnam (M), Ranga Reddy (Dist), Telangana, 501 510, India

4. Department of Pharmaceutics, Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala, 799 005, India

Abstract

Abstract: Alkaloids are waste products of plant metabolic processes, containing at least one nitrogen atom in the heterocyclic ring. They serve a wide variety of physiological functions in humans and animals. Metabolism plays a central role in regulating the toxicity of various phytochemicals. Available literature of biological sources and metabolism study of pyrrolidine, pyrrolizidine, pyridine, quinoline, isoquinoline, phenanthrene, phenethylamine, indole, terpenoid, and aporphine groups of experimental plantsderived alkaloids were collected from the Google Scholar, PubMed/Medline, Science Direct, Scopus, Wiley Online Library, and Web of Science search engines. The literature reveals that hepatic microsomal enzymes such as monooxygenase and putative NADPH-FMN-reductase, carboxyl esterase, CYP2B6, CYP3A4, and CYP2D6 are primarily involved in the metabolism of alkaloids. This review may encourage natural product researchers to further research and develop new plant-derived alkaloidal drugs.

Funder

Indian Council of Medical Research

All-India Council for Technical Education

Publisher

Bentham Science Publishers Ltd.

Subject

Organic Chemistry,Biochemistry

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