Affiliation:
1. Centre for Oral Bioengineering, Institute of Dentistry, Queen Mary University of London, Mile End Road, E1 4NS,
London, United Kingdom
Abstract
Abstract:
Natural polymers, such as chitosan (CH) and gelatine (GE), have a wide range of uses in biological
environments. This is primarily attributed to their biocompatibility and the body’s recognition of
them being as “self” as opposed to “foreign”. These polymers provide a dynamic and cell-friendly interaction
environment which is a crucial factor for tissue repair and regeneration. Bone regeneration is a
highly intricate multistep process involving a plethora of biomolecules, signalling pathways, and stages in
cellular activity. Critically-sized bone defects do not regenerate without an implant due to the cessation of
the cellular stimulus associated with new bone formation. Therefore, natural polymers have been combined
with bioactive glasses (BGs) to provide a biocompatible delivery matrix and to stimulate bone formation
via the release of osteogenic ions from the BG particles. The addition of BG particles in natural
polymers has been shown not only to result in an osteogenic response at a cellular level but also result in
per se formation of hydroxyapatite (HA) on implant surfaces and regeneration of new bone in vivo. This
review discusses the recent trends over the last decade in this field, keeping a focus on the chemistry and
properties of CH and GE composites containing a bioactive glass additive.
Publisher
Bentham Science Publishers Ltd.
Subject
Organic Chemistry,Biochemistry
Cited by
1 articles.
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