Role of the Pharmacist in the Management of Polypharmacy and Drug Interactions in the Elderly Patient with Chemotherapy-Reference-Cited by-同舟云学术

Role of the Pharmacist in the Management of Polypharmacy and Drug Interactions in the Elderly Patient with Chemotherapy

Published:2024-01 Issue:1 Volume:20 Page:2-11
ISSN:1573-3947
Container-title:Current Cancer Therapy Reviews
language:en
Short-container-title:CCTR

Author:

de Souza Silvania Maria Saldanha¹,Soares José Cleberson Santos²,Cavalcanti Iago Dillion Lima³

Affiliation:

1. Faculdade do Instituto de Desenvolvimento Educacional (IDE), Recife, Pernambuco, Brazil

2. Laboratório de Química e Inovação Terapêutica, Universidade Federal de Pernambuco (UFPE), Recite, Brazil

3. Instituto Keizo Asami (iLIKA), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil

Abstract

Introduction: This study aimed to review the role of the pharmacist in cases of polypharmacy in the care of elderly patients with cancer. Methods: An narrative literature review was carried out using the descriptors "Polypharmacy", "Pharmacological interactions", "Geriatrics" and "Antineoplastic agents", in the ScienceDirect, MEDLINE, and CAPLUS databases. Results: One hundred and ten articles were identified, of which 82 were included in this review. The articles showed the importance of evaluating drug interactions in the treatment of cancer in oncogeriatric patients due to the high amount of drugs that these patients use, which can exceed 6 drugs per day, and that these interactions can compromise the treatment of the patient, as well as induce serious toxic effects, causing the patient to be hospitalized or even die. Conclusion: The inclusion of the pharmacist in the care of oncogeriatric patients reduces the risk of interaction through pharmacotherapeutic monitoring.

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Oncology,Molecular Medicine

Reference96 articles.

1. Duarte M.B.; Rego M.A.V.; Comorbidity between depression and clinical diseases in a geriatric outpatient clinic. Cad Saude Publica 2007,23(3),691-700

2. Melgaço T.B.; Carrera J de S.; do Nascimento D.E.B.; Maia C do SF. Polypharmacy and occurrences of possible drug interactions. Rev Med 2011,25(1)

3. Leal M.C.C.; Marques A.P.O.; Marino J.G.; Austregésilo S.C.; Profile of nursing homes in the city of Recife, PE, Brazil. Rev Bras Geriatr Gerontol 2006,9(3),39-48

4. Vespa J.; Medina L.; Armstrong D.M.; Demographic turning points for the United States: Population projections for 2020 to 2060 US Census Bur 2020,1-15

5. Extermann M.; Measurement and impact of comorbidity in older cancer patients. Crit Rev Oncol Hematol 2000,35(3),181-200