Affiliation:
1. Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Federal University of
Agriculture, P.M.B 2373, Makurdi, Benue State, Nigeria
Abstract
Background:
The emergence of new diseases poses therapeutic challenges in modern
medicine. Polyurethane hydrogels that comprise polyol, copolymer and extender could be prepared
from diverse chemical compounds with adjuvants such as ascorbic acid and sorbitol, among
others. Their mechano-physicochemical properties are functions of their biological activities.
Therefore, there is a need to assess their therapeutic potentials.
Methods:
Relevant literature on the synthesis and medical uses of polyurethane-hydrogels, polyurethane-
aerogels, and polyurethane-graphene nanocomposite materials was searched in order to
identify their sources, synthesis, mechanical and physiochemical properties, biomedical applications,
chirality, and the relevance of Lipinski's rule of five in the synthesis of oral polyurethane
nanocomposite materials.
Results:
The prepared hydrogels and aerogels could be used as polymer carriers for intradermal,
cutaneous, and intranasal drugs. They can be fabricated and used as prosthetics. In addition, the
strength modulus (tensile stress-tensile strain ratio), biodegradability, biocompatibility, and nontoxic
effects of the polyurethane hydrogels and aerogels are highly desirable properties. However,
body and environmental temperatures may contribute to their instability; hence, there is need to
improve the synthesis of aerogels and hydrogels of polyurethane in order to ensure that they can
last for many years. Alcoholism, diabetes, pyrogenic diseases, mechanical and physical forces, and
physiological variability may also reduce the life span of polyurethane aerogels and hydrogels.
Conclusion:
Synthesis of polyurethane hydrogel-aerogel complex that can be used in complex, rare
biomedical cases is of paramount importance. These hydrogels and aerogels may be hydrophobic,
hydrophilic, aerophobic-aerophilic or amphiphilic, and sometimes lipophilic, depending on
structural components and the intended biomedical uses. Polyurethane graphene nanocomposite
materials are used in the treatment of a myriad of diseases, including cancer and bacterial infection.
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Medicine,Neuropsychology and Physiological Psychology,General Neuroscience
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