L-Tartaric Acid Inhibits Diminazene-induced Vasorelaxation in Isolated Rat Aorta-Reference-Cited by-同舟云学术

L-Tartaric Acid Inhibits Diminazene-induced Vasorelaxation in Isolated Rat Aorta

Published:2024-03 Issue:1 Volume:22 Page:83-89
ISSN:1871-5257
Container-title:Cardiovascular & Hematological Agents in Medicinal Chemistry
language:en
Short-container-title:CHAMC

Author:

Amssayef Ayoub¹,Bouadid Ismail¹,Eddouks Mohamed¹

Affiliation:

1. Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, Errachidia, Morocco

Abstract

Aims: The study investigated the effect of L-tartaric acid on diminazene-indiuced vasorelaxation. Background: Diminazene is known to induce vasorelaxation through the stimulation of angiotensin- converting enzyme (ACE-2). Objective: This work was designed to study the effect of L-tartaric acid on diminazene-induced vasorelaxation using an ex vivo approach. Material and Methods: In the current investigation, the inhibitory effect of L-tartaric acid on diminazene-induced relaxation. Results: The results confirmed that L-tartaric acid was able to inhibit in a dose-dependent manner diminazene-induced vasorelaxation. Conclusion: This investigation provides important experimental evidence of the efficacy of Ltartaric acid in inhibiting diminazene-induced vasorelaxation.

Publisher

Bentham Science Publishers Ltd.

Subject

Cardiology and Cardiovascular Medicine,Pharmacology,Hematology

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