Affiliation:
1. Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, Samara, 443099, Russia
2. Department of Histology and Embryology, Samara State Medical University, Samara, 443099, Russia
Abstract
Abstract:
Statin drugs have long been used as a key component of lipid-lowering therapy, which
is necessary for the prevention and treatment of atherosclerosis and cardiovascular diseases. Many
studies focus on finding and refining new effects of statin drugs. In addition to the main lipidlowering
effect (blocking cholesterol synthesis), statin drugs have a number of pleiotropic effects,
including negative effects. The main beneficial effects of statin drugs on the components of the
cardiovascular system are: anti-ischemic, antithrombotic, anti-apoptotic, antioxidant, endothelioprotective,
anti-inflammatory properties, and a number of other beneficial effects. Due to these
effects, statin drugs are considered one of the main therapeutic agents for the management of patients
with cardiovascular pathologies. To date, many review manuscripts have been published on
the myotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity and diabetogenic effects of statins.
However, there are no review manuscripts considering the negative effect of statin drugs on myocardial
contractile cells (cardiomyocytes). The purpose of this review is to discuss the negative
effects of statin drugs on cardiomyocytes. Special attention is paid to the cardiotoxic action of
statin drugs on cardiomyocytes and the mechanisms of increased serum levels of cardiac troponins.
In the process of preparing this review, a detailed analysis of laboratory and experimental
data devoted to the study of the negative effects of statin drugs on cardiomyocytes was carried out.
The literature search was carried out with the keywords: statin drugs, negative effects, mechanisms,
cardiac troponins, oxidative stress, apoptosis. Thus, statin drugs can have a number of
negative effects on cardiomyocytes, in particular, increased oxidative stress, endoplasmic reticulum
stress, damage to mitochondria and intercalated discs, and inhibition of glucose transport into
cardiomyocytes. Additional studies are needed to confirm and clarify the mechanisms and clinical
consequences of the negative effects of statin drugs on cardiomyocytes.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology
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