Affiliation:
1. Department of Biotechnology, Transcripotome Lab, Center for Emerging Diseases, Jaypee Institute of Information
Technology, Noida, Sector- 62, Uttar Pradesh, India
Abstract
Abstract:
Aged garlic extract (AGE) is an odorless derivative of garlic prepared by extracting
garlic cloves in an aqueous solution for twenty months. During the process of aging, reactive organosulfur
compounds such as allicin present in garlic are converted to their stable isoforms such
as S- Allyl cysteine. The unstable organo sulfurs in garlic (Allium sativum L.) have been reported
to cause problems in the gastrointestinal (GI) tract with an extremely pungent odor to attain its
therapeutic potential. But these pharmacologically safer sulfur compounds of AGE have been studied
and reported to have exceptional therapeutic potential in human health and various diseases. SAllyl
cysteine (SAC), Diallyl disulfide (DADS), Diallyl trisulfide (DATS), S-allyl-mercaptocysteine
(SAMC), are the most studied organosulfur compounds in in-vitro as well as in-vivo research.
Biomedical research suggests that these phytoconstituents exhibit antioxidant, cardioprotective,
cancer preventive, neuroprotective, immunomodulatory, antilipidemic, antidiabetic, hepatoprotective,
and antiobesity effects. The therapeutic potential of aged garlic extract has been found to be
extensively beneficial in these conditions, and provide a vast future in biomedical chemistry, herbdrug
synergy and drug designing. The purpose of this review is to provide a mechanistic understanding
of various organosulfur compounds of AGE in human health and disease based on data
provided in the literature.
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology,Hematology
Cited by
2 articles.
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