A Therapeutic Journey of Pyridine-based Heterocyclic Compounds as Potent Anticancer Agents: A Review (From 2017 to 2021)-Reference-Cited by-同舟云学术

A Therapeutic Journey of Pyridine-based Heterocyclic Compounds as Potent Anticancer Agents: A Review (From 2017 to 2021)

Published:2022-09 Issue:15 Volume:22 Page:2775-2787
ISSN:1871-5206
Container-title:Anti-Cancer Agents in Medicinal Chemistry
language:en
Short-container-title:ACAMC

Author:

Khan Sikandar¹,Alrooqi Munira²,Alhumaydhi Fahad A.³,Asiri Saeed A.⁴,Alshamrani Meshal⁵,Mashraqi Mutaib M.⁶,Alzamami Ahmad⁷,Alshahrani Asma M.⁸,Aldahish Afaf A.⁹

Affiliation:

1. Department of Chemistry, University of Malakand, Chakdara, Khyber Pakhtunkhwa, Pakistan

2. Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia

3. Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia

4. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia

5. Department of Pharmaceutics, College of Pharmacy, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia

6. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia

7. College of Applied Medical science Clinical Laboratory science department Shaqra University, Saudi Arabia

8. Department of Clinical Pharmacy, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia

9. Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha, 62529, Saudi Arabia

Abstract

Abstract: Pyridine derivatives are the most common and significant heterocyclic compounds, which show their fundamental characteristics to various pharmaceutical agents and natural products. Pyridine derivatives possess several pharmacological properties and a broad degree of structural diversity that is most valuable for exploring novel therapeutic agents. These compounds have an extensive range of biological activities such as antifungal, antibacterial, anticancer, anti-obesity, anti-inflammatory, antitubercular, antihypertensive, antineuropathic, antihistaminic, antiviral activities, and antiparasitic. The potent therapeutic properties of pyridine derivatives allow medicinal chemists to synthesize novel and effective chemotherapeutic agents. Consequently, the imperative objective of this comprehensive review is to summarize and investigate the literature regarding recent advancements in pyridine-based heterocycles to treat several kinds of cancer. Furthermore, the performances of pyridine derivatives were compared with some standard drugs, including etoposide, sorafenib, cisplatin, and triclosan, against different cancer cell lines. We hope this study will support the new thoughts to pursue the most active and less toxic rational designs.

Publisher

Bentham Science Publishers Ltd.

Subject

Cancer Research,Pharmacology,Molecular Medicine

Reference74 articles.

1. Nural Y.; Ozdemir S.; Doluca O.; Demir B.; Yalcin M.S.; Atabey H.; Kanat B.; Erat S.; Sari H.; Seferoglu Z.; Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone-triazole hybrids. Bioorg Chem 2020,105,104441

2. Gemili, M.; Nural, Y.; Keleş, E.; Aydıner, B.; Seferoğlu, N.; Ülger, M.; Şahin, E.; Erat, S.; Seferoğlu, Z. Novel highly functionalized 1,4-naphthoquinone 2-iminothiazole hybrids: Synthesis, photophysical properties, crystal structure, DFT studies, and An-ti(Myco)Bacterial/Antifungal activity. J Mol Struct 2019,1196,536-546

3. Nural Y.; Gemili M.; Ulger M.; Sari H.; De Coen L.M.; Sahin E.; Synthesis, antimicrobial activity and acid dissociation constants of methyl 5,5-diphenyl-1-(thiazol-2-yl)pyrrolidine-2-carboxylate derivatives. Bioorg Med Chem Lett 2018,28(5),942-946

4. Gemili M.; Sari H.; Ulger M.; Sahin E.; Nural Y.; Pt(II) and Ni(II) Complexes of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives: Synthesis, characterization, physical parameters and biological activity. Inorg Chim Acta 2017,463,88-96

5. Nural Y.; Kilincarslan R.; Dondas H.A.; Cetinkaya B.; Serin M.S.; Grigg R.; Ince T.; Kilner C.; Synthesis of Ni(II), Pd(II) and Cu(II) metal complexes of novel highly functionalized aroylaminocarbo-N-thioyl pyrrolidines and their activity against fungi and yeast. Polyhedron 2009,28(14),2847-2854

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Redox reaction thiol-disulfide for 3-, 4- and 6-methyl-5-nitopyridine derivatives – X-ray, electron absorption and emission, IR and Raman studies discussed in term of quantum chemical DFT calculations;Journal of Molecular Structure;2024-12

2. Electrocyclization of α,β,γ,δ-unsaturated ferrocenyl aldehydes: Synthesis of novel ferrocenyl phenyl decorated pyridines;Journal of Organometallic Chemistry;2024-11

3. Recent advancement in organic fluorescent and colorimetric chemosensors for the detection of Al3+ ions: A review (2019–2024);Journal of Environmental Chemical Engineering;2024-10

4. Comprehensive Serum Proteomic and Metabolomic Profiles of Pediatric Patients with Moyamoya Disease Reveal Core Pathways;Journal of Inflammation Research;2024-09

5. Computational investigation of amide derivative as potential anti-carbapenem-resistant Pseudomonas aeruginosa;Journal of the Indian Chemical Society;2024-08