Affiliation:
1. Department of Health Science, University of la Salle, Bogotá, Colombia
Abstract
Abstract:
Glaucoma is a common cause of visual loss and irreversible blindness,
affecting visual and life quality. Various mechanisms are involved in retinal ganglion cell
(RGC) apoptosis and functional and structural loss in the visual system. The prevalence
of glaucoma has increased in several countries. However, its early diagnosis has
contributed to prompt attention. Molecular and cellular biological mechanisms are
important for understanding the pathological process of glaucoma and new therapies.
Thus, this review discusses the factors involved in glaucoma, from basic science to
cellular and molecular events (e.g., mitochondrial dysfunction, endoplasmic reticulum
stress, glutamate excitotoxicity, the cholinergic system, and genetic and epigenetic
factors), which in recent years have been included in the development of new therapies,
management, and diagnosis of this disease.
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry
Cited by
2 articles.
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