Transcriptomic Signatures in Colorectal Cancer Progression

Abstract

Aims: Due to a large number of identified hub-genes encoding key molecular regulators, which are involved in signal transduction and metabolic pathways in cancers, it is relevant to systemize and update these findings. Background: Colorectal cancer (CRC) is the third leading cause of cancer death in the world, with high metastatic potential. Elucidating the pathogenic mechanisms and selection of novel biomarkers in CRC is of great clinical significance. Objective: This analytical review aims at systematization of bioinformatics and experimental identification of hub-genes, associated with CRC, for a more consolidated understanding of common features in networks and pathways in CRC progression as well as hub-genes selection. Results: This analytical review aims at the systematization of bioinformatics and experimental identification of hub-genes associated with CRC for a more consolidated understanding of common features in networks and pathways in CRC progression as well as hub-genes selection. Conclusion: Results obtained are of useful fundamental information on revealing the mechanism of pathogenicity, cellular target selection for optimization of therapeutic interventions, as well as transcriptomics prognostic and predictive biomarkers development.