Natural Compounds as Integrative Therapy for Liver Protection against Inflammatory and Carcinogenic Mechanisms: From Induction to Molecular Biology Advancement

Author:

Pathak Surajit1,Marotta Francesco2,Banerjee Antara1,Sriramulu Sushmitha1,Catanzaro Roberto3,He Fang4,Chabria Yashna1,Balakrishnan Baskar5,Hari Sruthi1,Ayala Antonio6,Muñoz Mario7

Affiliation:

1. Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education (CARE), Chettinad Hospital and Research Institute (CHRI), Chennai 603103, India

2. ReGenera R&D International for Aging Intervention, Milano, Italy and Vitality and Longevity Medical Science Commission, FEMTEC World Federation

3. Dept of Clinical and Experimental Medicine, Section of Gastroenterology, University of Catania, Catania, Italy

4. Dept of Nutrition, West China School of Public Health, Sichuan University, Chengdu, China

5. Department of Immunology, Mayo Clinic, Rochester, MN, USA

6. Biochemistry and Clinical Biochemistry Department, Faculty of Pharmacy, University of Seville, Spain

7. Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Portugal

Abstract

Abstract: The liver is exposed to several harmful substances that bear the potential to cause excessive liver damage ranging from hepatitis and non-alcoholic fatty liver disease to extreme cases of liver cirrhosis and hepatocellular carcinoma. Liver ailments have been effectively treated from very old times with Chinese medicinal herbal formulations and later also applied by controlled trials in Japan. However, these traditional practices have been hardly well characterized in the past till in the last decades when more qualified studies have been carried out. Modern advances have given rise to specific molecular targets which are specifically good candidates for affecting the intricate mechanisms that play a role at the molecular level. These therapeutic regimens that mainly affect the progression of the disease by inhibiting the gene expression levels or by blocking essential molecular pathways or releasing cytokines may prove to play a vital role in minimizing the tissue damage. This review, therefore, tries to throw light upon the variation in the therapies for the treatment of benign and malignant liver disease from ancient times to the current date. Nonetheless, clinical research exploring the effectiveness of herbal medicines in the treatment of benign chronic liver diseases as well as prevention and treatment of HCC is still warranted.

Publisher

Bentham Science Publishers Ltd.

Subject

Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

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