Diagnostic, prognostic, and therapeutic value of miR-148b in human cancers
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Published:2021-12-13
Issue:
Volume:21
Page:
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ISSN:1566-5240
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Container-title:Current Molecular Medicine
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language:en
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Short-container-title:CMM
Author:
Bahrami Afsane1,
Ferns Gordon A.2
Affiliation:
1. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
2. Division of Medical Education, Brighton & Sussex Medical School, Brighton, Sussex, United Kingdom
Abstract
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MicroRNAs (miRs) is a class of conserved, small, noncoding RNA molecules which modulate gene expression post-transcriptionally. miR-148b is a member of miR-148/152 family generally known to be a tumor suppressor via its affect on different signaling pathways and regulatory genes. Aberrant expression of miR-148b has recently been shown to be responsible for tumorigenesis for several different cancer types. This review discusses the current evidences regarding the involvement of miR-148b expression in human cancers and its potential clinical importance for tumor diagnosis, prognosis, and therapeutics.
Publisher
Bentham Science Publishers Ltd.
Subject
Molecular Biology,Molecular Medicine,General Medicine,Biochemistry