Intra Nasal In situ Gelling System of Lamotrigine Using Ion Activated Mucoadhesive Polymer

Abstract

Background:A novel drug delivery system for treating acute epileptic condition.Objective:To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loadedinsitugel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment.Methods:Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum.Results:All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range.Invitrodrug release from the mucoadhesiveinsitugel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min.Exvivopermeation studies of optimized formulation G5 and control formulation was estimated.Exvivopermeation studies of G5insituformulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2ºC).Conclusion:The intranasalinsitugelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions.