Affiliation:
1. Faculty of Pharmacy, IFTM University, Moradabad - 244102, India
2. Department of Pharmacy, Noida Institute of Engineering and Technology, Greater Noida - 201306, India
3. School of Pharmacy & Technology Management, SVKM’s NMIMS (Deemed to be University), Shirpur, Distt - Dhule - 425405, India
Abstract
Background:
Oxadiazole core displays various pharmacological properties among five
membered nitrogen heterocyclic compounds, specially 1,3,4-oxadiazole containing molecules that
have occupied a particular place in the field of synthetic medicinal chemistry as surrogates (bioisosteres)
of carboxylic acids, carboxamides and esters. Moreover, they are having widespread kind
of applications in numerous zones as polymers, as luminescence producing materials and as electron-
transporting materials and corrosion inhibitors.
Methods:
This study contains comprehensive and extensive literature survey on chemical reactivity
and biological properties associated with 1,3,4-oxadiazole containing compounds.
Results:
This review summarises 1,3,4-oxadiazole moiety in numerous compounds with reported
pharmacological activity such as antiviral, analgesic and anti-inflammatory, antitumor, antioxidant,
insecticidal and anti-parasitic, etc. Nevertheless, ring opening reactions of the 1,3,4-oxadiazole
core have also made great attention, as they produce new analogues containing an aliphatic nitrogen
atom and to other ring systems.
Conclusion:
In relation to the occurrence of oxadiazoles in biologically active molecules, 1,3,4-
oxadiazole core emerges as a structural subunit of countless significance and usefulness for the development
of new drug aspirants applicable to the treatment of many diseases. It concludes that
1,3,4-oxadiazole core compounds are more efficacious and less toxic medicinal agents with respect
to new opinions in the search for rational strategies.
Publisher
Bentham Science Publishers Ltd.
Subject
Psychiatry and Mental health
Cited by
17 articles.
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1. Exploring the effect of substituents on the supramolecular assemblies built by non-covalent interactions in three closely related 1,3,4-oxadiazole-2(3H)-thione derivatives: An evaluation of antimicrobial and anti-proliferative activities;Journal of Molecular Structure;2024-04
2. DFT Computational Studies, Spectroscopic (UV–Vis, IR, NMR), In Silico Molecular Docking and ADME Study of 3-(3-Methylpyridin-2-yl)-5-phenyl-1,2,4-oxadiazole;Journal of Molecular Structure;2024-01
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4. Synthesis, antimicrobial activity, and in silico studies of fluoroquinolones bearing 1,3,4‐oxadiazolyl‐triazole derivatives;Journal of Heterocyclic Chemistry;2023-08-21
5. Multicomponent Domino Reaction for Concise Access to 2-Amino-Substituted 1,3,4 Oxadiazoles via Smiles Rearrangement;The Journal of Organic Chemistry;2023-08-10