Recent Advances on the Antimicrobial Activities of Schiff Bases and their Metal Complexes: An Updated Overview

Author:

Rafique Jamal1ORCID,Jorge Juliana1ORCID,Fanti Del Pino Santos Kristiane1ORCID,Timáteo Fernanda1ORCID,Rodrigo Piva Vasconcelos Rafael1ORCID,Ignacio Ayala Cáceres Osmar1ORCID,Juliane Arantes Granja Isis2ORCID,Monteiro de Souza David1ORCID,Elias Allievi Frizon Tiago3ORCID,Di Vaccari Botteselle Giancarlo4ORCID,Luiz Braga Antonio5ORCID,Saba Sumbal2ORCID,Haroon ur Rashid 5ORCID

Affiliation:

1. Federal University of Mato Grosso do Sul Institute of Chemistry Campo Grande Brazil

2. Universidade Federal de Goiás Institute of Chemistry Goiânia Brazil

3. Universidade Federal de Santa Catarina Department of Energy and Sustainability Florianópolis Brazil

4. Universidade Estadual do Centro-Oeste Department of Chemistry Guarapuava Brazil

5. Universidade Federal de Santa Catarina Department of Chemistry Florianópolis Brazil

Abstract

Abstract: Schiff bases represent a valuable class of organic compounds, synthesized via condensation of primary amines with ketones or aldehydes. They are renowned for possessing innumerable applications in agricultural chemistry, organic synthesis, chemical and biological sensing, coating, polymer and resin industries, catalysis, coordination chemistry, and drug designing. Schiff bases contain imine or azomethine (–C=N–) functional groups which are important pharmacophores for the design and synthesis of lead bioactive compounds. In medicinal chemistry, Schiff bases have attracted immense attention due to their diverse biological activities. This review aims to encompass the recent developments on the antimicrobial activities of Schiff bases. The article summarizes the antibacterial, antifungal, antiviral, antimalarial, and antileishmanial activities of Schiff bases reported since 2011.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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