Affiliation:
1. Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, Samara,
443099, Russia
2. Department of Histology and Embryology, Samara State Medical University, Samara,
443099, Russia
Abstract
Abstract:
To date, it is well known that a significant number of diseases of cardiovascular
genesis (coronary heart disease, myocardial infarction, cardiomyopathy, Takotsubo
syndrome, heart failure, etc.) and extra-cardiac genesis (renal failure, chronic obstructive
pulmonary disease, sepsis, diabetes mellitus, etc.) cause injury to contractile cells of the
heart muscle (myocardial cells). The most sensitive and specific criteria for proving myocardial
cell injury are cardiospecific troponins (CSTns) - CSTnI and CSTnT. According
to the current clinical recommendations of the European, American, and Russian Cardiological
Communities, CSTnI and CSTnT are the main biomarkers for early diagnosis of
myocardial infarction. Hypertension is one of the most dangerous and common risk factors
for the development of cardiovascular pathologies and is associated with a high risk
of dangerous cardiovascular complications. Therefore, there is an urgent need to search
for new biomarkers for the timely assessment of the prognosis of patients with hypertension.
:
This mini-review aims to substantiate the possibilities of using the cardiomarkers (CSTnI
and CSTnT) to assess the prognosis of patients suffering from hypertension and to discuss
potential mechanisms that cause injury to myocardial cells and increase serum levels
of CSTnI and CSTnT.
:
This is a narrative mini-review, which was prepared using the following databases:
Pubmed/Medline, PubMed Central, Embase, Scopus, and Web of Science. The following
keywords were used in the literature search: “myocardial cells”, “injury”, “damage”, and
“hypertension” in combination with the terms “mechanisms of injury” “predictive significance”,
“cardiac troponins”, or “cardiospecific troponins”.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry