Naturally Occurring Xanthones; Biological Activities, Chemical Profiles and In Silico Drug Discovery

Author:

El-Seedi Hesham R.123,Ibrahim Hasnaa M.S.2,Yosri Nermeen4,Ibrahim Mahmoud A.A.5,Hegazy Mohamed-Elamir F.67,Setzer William N.89,Guo Zhiming10,Zou Xiaobo10,Refaey Mohamed S.11,Salem Suhila E.12,Musharraf Syed G.13,Saeed Aamer14,Salem Sara E.15,Xu Baojun16,Zhao Chao17,Khalifa Shaden A.M.18

Affiliation:

1. International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China

2. Department of Chemistry, Faculty of Science, Menoufia University, 32512, Shebin El-Kom, Egypt

3. International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Nanjing, 210024, China

4. Chemistry of Natural Products, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef, 62514, Egypt

5. Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt

6. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudingerweg 5, Mainz, 55128, Germany

7. 7Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt

8. Department of Chemistry, University of Alabama in Huntsville, Huntsville, 35899, AL, USA

9. Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, 84043, UT, USA

10. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China

11. Department of Pharmacognosy, Faculty of Pharmacy, University of Sadat City, Menoufia 32897, Egypt

12. Clinical Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

13. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

14. Chemistry Department, Quaid-i-Azam University, Islamabad, 45320, Pakistan

15. Faculty of Pharmacy, The British University in Egypt, El Sherouk, Cairo, Egypt

16. Food Science and Technology Program, BNU-HKBU United International College, Zhuhai, 519087, China

17. College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China

18. Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, SE 106 91, Sweden

Abstract

Abstract: Xanthones are widely distributed polyphenols, present commonly in higher plants; Garcinia, Calophyllum, Hypericum, Platonia, Mangifera, Gentiana and Swertia. Xanthone tricyclic scaffold is able to interact with different biological targets, showing antibacterial and cytotoxic effects, as well as potent effects against osteoarthritis, malaria, and cardiovascular diseases. Thus, in this article we focused on pharmacological effects, applications and preclinical studies with the recent updates of xanthon´s isolated compounds from 2017-2020. We found that only α-mangostin, gambogic acid, and mangiferin, have been subjected to preclinical studies with particular emphasis on the development of anticancer, diabetes, antimicrobial and hepatoprotective therapeutics. Molecular docking calculations were performed to predict the binding affinities of xanthone-derived compounds against SARS-CoV-2 Mpro. According to the results, cratoxanthone E and morellic acid demonstrated promising binding affinities towards SARS-CoV-2 Mpro with docking scores of −11.2 and −11.0 kcal/mol, respectively. Binding features manifested the capability of cratoxanthone E and morellic acid to exhibit nine and five hydrogen bonds, respectively, with the key amino acids of the Mpro active site. In conclusion, cratoxanthone E and morellic acid are promising anti-COVID-19 drug candidates that warrant further detailed in vivo experimental estimation and clinical assessment.

Funder

Science and Technology Development Fund, STDF, Egypt

Ministry of Science and Technology, China

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3