Translational Research of Hemoglobin Vesicles as a Transfusion Alternative
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Published:2022-01
Issue:3
Volume:29
Page:591-606
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ISSN:0929-8673
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Container-title:Current Medicinal Chemistry
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language:en
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Short-container-title:CMC
Author:
Sakai Hiromi1ORCID,
Kobayashi Naoko1ORCID,
Kure Tomoko1ORCID,
Okuda Chie1ORCID
Affiliation:
1. Department of Chemistry, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521,Japan
Abstract
:
Clinical situations arise in which blood for transfusion becomes scarce or unavailable.
Considerable demand for a transfusion alternative persists because of various
difficulties posed by blood donation and transfusion systems. Hemoglobin-vesicles (Hb-
V) are artificial oxygen carriers being developed for use as a transfusion alternative. Just
as biomembranes of red blood cells (RBCs) do, phospholipid vesicles (liposomes) for Hb
encapsulation can protect the human body from the toxic effects of molecular Hb. The
main HbV component, Hb, is obtained from discarded human donated blood. Therefore,
HbV can be categorized as a biologic agent targeting oxygen for peripheral tissues. The
purification procedure strictly eliminates the possibility of viral contamination. It also removes
all concomitant unstable enzymes present in RBC for utmost safety from infection.
The deoxygenated HbVs, which are storable for over the years at ambient temperature,
can function as an alternative to blood transfusion for resuscitation from hemorrhagic
shock and O2 therapeutics. Moreover, a recent study clarified beneficial effects for anti-
oxidation and anti-inflammation by carbon monoxide (CO)-bound HbVs. Autoxidation
of HbV (HbO2 → metHb + O2
-.) is unavoidable after intravenous administration. Co-injection
of methylene blue can extract the intraerythrocytic glycolytic electron energy effectively
and reduce metHb. Other phenothiazine dyes can also function as electron mediators
to improve the functional life span of HbV. This review paper summarizes recent
progress of the research and development of HbV, aimed at clinical applications.
Funder
Grant-in-Aid for Scientific Research from the, Japan Society for the Promotion of Sciences
Health, Labour and Sciences Research Grant, Ministry of Health, Labour and Welfare, Japan
Japan Agency for Medical Research and Development, AMED
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
12 articles.
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