Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease


Shibu Marthandam Asokan1ORCID,Bharath Mahalakshmi2ORCID,Velmurugan Bharath Kumar3ORCID


1. Cardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

2. Department of Research and Development, Vels Publisher, Bodinayakanur, Tamil Nadu, Vietnam

3. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan


Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it’s underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.


Bentham Science Publishers Ltd.


Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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1. Interaction between macrophages and ferroptosis;Cell Death & Disease;2022-04







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