Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease

Author:

Shibu Marthandam Asokan1ORCID,Bharath Mahalakshmi2ORCID,Velmurugan Bharath Kumar3ORCID

Affiliation:

1. Cardiovascular and Mitochondria Related Diseases Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan

2. Department of Research and Development, Vels Publisher, Bodinayakanur, Tamil Nadu, Vietnam

3. Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan

Abstract

Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it’s underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Interaction between macrophages and ferroptosis;Cell Death & Disease;2022-04

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