Novel Vaccine Candidates against Tuberculosis-Reference-Cited by-同舟云学术

Novel Vaccine Candidates against Tuberculosis

Published:2020-09-11 Issue:31 Volume:27 Page:5095-5118
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Li Zhihao¹,Zheng Changping¹,Terreni Marco²,Tanzi Lisa²,Sollogoub Matthieu¹,Zhang Yongmin¹

Affiliation:

1. Sorbonne Universite, CNRS, Institut Parisien de Chimie Moleculaire (UMR 8232), 4 Place Jussieu, 75005 Paris, France

2. Drug Sciences Department, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy

Abstract

Ranking above AIDS, Tuberculosis (TB) is the ninth leading cause of death affecting and killing many individuals every year. Drugs’ efficacy is limited by a series of problems such as Multi- Drug Resistance (MDR) and Extensively-Drug Resistance (XDR). Meanwhile, the only licensed vaccine BCG (Bacillus Calmette-Guérin) existing for over 90 years is not effective enough. Consequently, it is essential to develop novel vaccines for TB prevention and immunotherapy. This paper provides an overall review of the TB prevalence, immune system response against TB and recent progress of TB vaccine research and development. Several vaccines in clinical trials are described as well as LAM-based candidates.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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