Oxazole-Based Compounds As Anticancer Agents-Reference-Cited by-同舟云学术

Oxazole-Based Compounds As Anticancer Agents

Published:2020-01-08 Issue:41 Volume:26 Page:7337-7371
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Chiacchio Maria A.¹,Lanza Giuseppe¹,Chiacchio Ugo¹,Giofrè Salvatore V.²,Romeo Roberto²,Iannazzo Daniela³,Legnani Laura¹

Affiliation:

1. Dipartimento di Scienze del Farmaco, University of Catania, V.le Doria 6, 95125 Catania, Italy

2. Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, University of Messina, Via S.S. Annunziata, 98168 Messina, Italy

3. Dipartimento di Ingegneria, University of Messina, Contrada Di Dio, 98166 Messina, Italy

Abstract

: Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

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