The Innate Immune System and Fever under Redox Control: A Narrative Review-Reference-Cited by-同舟云学术

The Innate Immune System and Fever under Redox Control: A Narrative Review

Published:2022-08 Issue:25 Volume:29 Page:4324-4362
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Henrik Szőke¹^ORCID,István Bókkon²^ORCID,David Martin³,Jan Vagedes⁴,Ágnes Kiss⁵,Zoltán Kovács⁵,Ferenc Fekete⁶,Tibor Kocsis⁷,László Szijjártó⁸,Ádám Dobrylovsky⁹,Odilia Mussler⁹,Andrea Kisbenedek¹

Affiliation:

1. Doctoral School of Health Sciences, University of Pécs, Pécs, Hungary | Faculty of Health Sciences, University of Pécs, Pécs, Hungary

2. Neuroscience and Consciousness Research Department, Vision Research Institute, Lowell, MA, USA

3. Department of Human Medicine, University Witten/Herdecke, Witten, Germany | University Children’s Hospital, Tuebingen University, Tuebingen, Germany

4. University Children’s Hospital, Tuebingen University, Tuebingen, Germany | ARCIM Institute (Academic Research in Complementary and Integrative Medicine), Filderstadt, Germany

5. Doctoral School of Health Sciences, University of Pécs, Pécs, Hungary

6. Department of Nyerges Gábor Pediatric Infectology, Heim Pál National Pediatric Institute, Budapest, Hungary

7. Department of Clinical Governance, Hungarian National Ambulance Service, Budapest, Hungary

8. Department of Pedietric Pulmonology, Karolina Hospital, Mosonmagyaróvár, Hungary

9. Clinic Arlesheim, Arlesheim, Swiss, Switzerland

Abstract

Abstract: In living cells, redox potential is vitally important for normal physiological processes that are closely regulated by antioxidants, free amino acids, and proteins that either have reactive oxygen and nitrogen species capturing capability or can be compartmentalized. Although hundreds of experiments support the regulatory role of free radicals and their derivatives, several authors continue to claim that these perform only harmful and non-regulatory functions. In this paper, we demonstrate that countless intracellular and extracellular signal pathways are directly or indirectly linked to regulated redox processes. We also briefly discuss how artificial oxidative stress can have important therapeutic potential and the possible negative effects of popular antioxidant supplements. Next, we present the argument supported by a large number of studies that many of the major components of innate immunity and fever are essentially associated with redox processes. Our goal is to point out that the production of excess or unregulated free radicals and reactive species can be secondary processes due to the perturbed cellular signal pathways. However, research on pharmacology should consider the important role of redox mechanisms in the innate immune system and fever.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry

Reference369 articles.

1. Wang K.; Dong Y.; Liu J.; Qian L.; Wang T.; Gao X.; Wang K.; Zhou L.; Effects of REDOX in regulating and treatment of metabolic and inflammatory cardiovascular diseases. Oxid Med Cell Longev 2020,2020,5860356

2. Dröge W.; Free radicals in the physiological control of cell function. Physiol Rev 2002,82(1),47-95

3. Valko M.; Leibfritz D.; Moncol J.; Cronin M.T.; Mazur M.; Telser J.; Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007,39(1),44-84

4. Pham-Huy L.A.; He H.; Pham-Huy C.; Free radicals, antioxidants in disease and health. Int J Biomed Sci 2008,4(2),89-96

5. Egea J.; Fabregat I.; Frapart Y.M.; Ghezzi P.; Görlach A.; Kietzmann T.; Kubaichuk K.; Knaus U.G.; Lopez M.G.; Olaso-Gonzalez G.; Petry A.; Schulz R.; Vina J.; Winyard P.; Abbas K.; Ademowo O.S.; Afonso C.B.; Andreadou I.; Antelmann H.; Antunes F.; Aslan M.; Bachschmid M.M.; Barbosa R.M.; Belousov V.; Berndt C.; Bernlohr D.; Bertrán E.; Bindoli A.; Bottari S.P.; Brito P.M.; Carrara G.; Casas A.I.; Chatzi A.; Chondrogianni N.; Conrad M.; Cooke M.S.; Costa J.G.; Cuadrado A.; My-Chan Dang P.; De Smet B.; Debelec-Butuner B.; Dias I.H.K.; Dunn J.D.; Edson A.J.; El Assar M.; El-Benna J.; Ferdinandy P.; Fernandes A.S.; Fladmark K.E.; Förstermann U.; Giniatullin R.; Giricz Z.; Görbe A.; Griffiths H.; Hampl V.; Hanf A.; Herget J.; Hernansanz-Agustín P.; Hillion M.; Huang J.; Ilikay S.; Jansen-Dürr P.; Jaquet V.; Joles J.A.; Kalyanaraman B.; Kaminskyy D.; Karbaschi M.; Kleanthous M.; Klotz L.O.; Korac B.; Korkmaz K.S.; Koziel R.; Kračun D.; Krause K.H.; Křen V.; Krieg T.; Laranjinha J.; Lazou A.; Li H.; Martínez-Ruiz A.; Matsui R.; McBean G.J.; Meredith S.P.; Messens J.; Miguel V.; Mikhed Y.; Milisav I.; Milković L.; Miranda-Vizuete A.; Mojović M.; Monsalve M.; Mouthuy P.A.; Mulvey J.; Münzel T.; Muzykantov V.; Nguyen I.T.N.; Oelze M.; Oliveira N.G.; Palmeira C.M.; Papaevgeniou N.; Pavićević A.; Pedre B.; Peyrot F.; Phylactides M.; Pircalabioru G.G.; Pitt A.R.; Poulsen H.E.; Prieto I.; Rigobello M.P.; Robledinos-Antón N.; Rodríguez-Mañas L.; Rolo A.P.; Rousset F.; Ruskovska T.; Saraiva N.; Sasson S.; Schröder K.; Semen K.; Seredenina T.; Shakirzyanova A.; Smith G.L.; Soldati T.; Sousa B.C.; Spickett C.M.; Stancic A.; Stasia M.J.; Steinbrenner H.; Stepanić V.; Steven S.; Tokatlidis K.; Tuncay E.; Turan B.; Ursini F.; Vacek J.; Vajnerova O.; Valentová K.; Van Breusegem F.; Varisli L.; Veal E.A.; Yalçın A.S.; Yelisyeyeva O.; Žarković N.; Zatloukalová M.; Zielonka J.; Touyz R.M.; Papapetropoulos A.; Grune T.; Lamas S.; Schmidt H.H.H.W.; Di Lisa F.; Daiber A.; European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol 2017,13,94-162

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A láz kezelésének modern szemléletéről a LázBarátTM program első eredményeinek fényében;Orvosi Hetilap;2023-02-05

2. Antioxidants Mitigate Oxidative Stress: A General Overview;Food Bioactive Ingredients;2023