Nanoinformatics and Personalized Medicine: An Advanced Cumulative Approach for Cancer Management

Abstract

Background: Even though the battle against cancer has advanced remarkably in last few decades and the survival rate has improved very significantly, an ultimate cure for cancer treatment stills remains an undeterred problem. In such scenario, nanoinformatics, which is bioinformatics coupled with nanotechnology, endows with many novel research opportunities in the preclinical and clinical development of specially personalized nanosized drugs and carriers bestowing newer dimensions in anticancer research and therapy. Personalized nanomedicines tends to serve as a promising treatment option for cancer owing to their noninvasiveness and their novel approach. Explicitly, the field of personalized medicine is expected to have an enormous impact in clinical research owing to its diverse advantages and its versatility to adapt a drug to a cohort of patients. Objective: The current review attempts to explain the implications of nanoinformatics as a new emerging field in the field of pharmacogenomics and precision medicine. This review also recapitulates how nanoinformatics could accelerate the developments of personalized nanomedicine in anticancer research, which is undoubtedly the need of the hour. Conclusion: The approach and concept of personalized nanomedicine has been facilitated by humongous impending field of Nanoinformatics. The breakthrough progressions made through nanoinformatics have prominently changed the insight of the future personalized medicinal drug in cancer research. Nanoparticle based medicine has been developing and has created a center of attention in recent years, with a prime focus on proficient delivery mechanisms for various chemotherapy drugs. Nanoinformatics has allowed merging of all recent advances from creating nanosized particles that contain drugs targeting cell surface receptors to other potent molecules designed to kill cancerous cells and its subsequent application to personalize medicine.