Affiliation:
1. Biotechnology Institute, Ankara University, Kecioren, Ankara, Turkey
Abstract
Abstract:
Ferroptosis is a recently discovered type of cell death caused by the accumulation
of iron-dependent lipid peroxides and reactive oxygen species that differs significantly
from other cell death pathways such as apoptosis, necrosis, and autophagy. Ferroptosis
is essential in developing and treating ischemia-reperfusion injury, neurological diseases,
cancer, and other diseases. The ferroptosis mechanism, which can be induced by reagents
like erastin and glutamate, and suppressed by antioxidants such as vitamin E and deferoxamine
(DFO) chelators, can be regulated at the epigenetic, transcriptional, post-transcriptional,
and post-translational levels. A recent study has determined many non-coding
RNAs (lncRNA, miRNA, circRNA) that modulate ferroptotic cell death in cancer cells.
Furthermore, some anti-cancer drugs (Sorafenib, Sulfasalazine, Acetominofen, Lanperisone,
etc.) used in pre-clinical and clinical applications have been shown to induce ferroptosis
in various cancer types. However, in addition to the studies in the literature, it is necessary
to define novel molecules & non-coding RNAs and determine their effects on the
ferroptosis mechanism. Thus, it will be possible to develop effective and safe treatment
options.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry