Affiliation:
1. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, School of Chemistry and
Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China
2. Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314019, China
Abstract
Abstract:
Adult hippocampal neurogenesis is a multistage mechanism that continues
throughout the lifespan of human and non-human mammals. These adult-born neurons in
the central nervous system (CNS) play a significant role in various hippocampus-dependent
processes, including learning, mood regulation, pattern recognition, etc. Reduction
of adult hippocampal neurogenesis, caused by multiple factors such as neurological disorders
and aging, would impair neuronal proliferation and differentiation and result in memory
loss. Accumulating studies have indicated that functional neuron impairment could
be restored by promoting adult hippocampal neurogenesis. In this review, we summarized
the small molecules that could efficiently promote the process of adult neurogenesis,
particularly the agents that have the capacity of crossing the blood-brain barrier (BBB),
and showed in vivo efficacy in mammalian brains. This may pave the way for the rational
design of drugs to treat human neurodegenerative disorders in the future.
Funder
China's National Natural Science Foundation
China's National Key Research and Development Program
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献