Affiliation:
1. Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease
Research of Hunan Province, Institute of Cardiovascular Disease, University of South China, Hengyang,
China, 421001
Abstract
Abstract:
Lipid metabolism is a complex biochemical process that regulates normal cell
activity and death. Ferroptosis is a novel mode of programmed cell death different from
apoptosis, pyroptosis, and autophagy. Abnormal lipid metabolism may lead to lipid peroxidation
and cell rupture death, which are regulated by lipoxygenase (LOX), long-chain
acyl-coA synthases, and antioxidant enzymes. Alternatively, Fe2+ and Fe3+ are required
for the activity of LOXs and ferroptosis, and Fe2+ can significantly accelerate lipid peroxidation
in ferroptosis. Abnormal lipid metabolism is a certain risk factor for cardiovascular
disease. In recent years, the important role of ferroptosis in developing cardiovascular
disease has been increasingly reported. Reducing lipid accumulation could reduce the occurrence
of ferroptosis, thus alleviating cardiovascular disease deterioration. This article
reviews the relationship of lipid peroxidation to the general mechanism of ferroptosis and
highlights lipid peroxidation as the common point of ferroptosis and cardiovascular disease.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
5 articles.
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