Affiliation:
1. Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin 541004, China
2. Department of Chemistry, Faculty of Science, The University of British Columbia, 2036 Main Mall Vancouver, British Columbia V6T 1Z1, Canada
Abstract
Background:
Hepatocellular carcinoma (HCC) seriously affects human health, especially,
it easily develops multi-drug resistance (MDR) which results in treatment failure. There is an
urgent need to develop highly effective and low-toxicity therapeutic agents to treat HCC and to
overcome its MDR. Targeted drug delivery systems (DDS) for cancer therapy, including nanoparticles,
lipids, micelles and liposomes, have been studied for decades. Recently, more attention has
been paid to multifunctional DDS containing various ligands such as polymer moieties, targeting
moieties, and acid-labile linkages. The polymer moieties such as poly(ethylene glycol) (PEG), chitosan
(CTS), hyaluronic acid, pullulan, poly(ethylene oxide) (PEO), poly(propylene oxide) (PPO)
protect DDS from degradation. Asialoglycoprotein receptor (ASGPR) and glycyrrhetinic acid receptor
(GAR) are most often used as the targeting moieties, which are overexpressed on hepatocytes.
Acid-labile linkage, catering for the pH difference between tumor cells and normal tissue, has
been utilized to release drugs at tumor tissue.
Objectives:
This review provides a summary of the recent progress in ASGPR and GAR-mediated
and/or pH-responsive HCC-targeted drug delivery.
Conclusion:
The multifunctional DDS may prolong systemic circulation, continuously release
drugs, increase the accumulation of drugs at the targeted site, enhance the anticancer effect, and
reduce side effects both in vitro and in vivo. But it is rarely used to investigate MDR of HCC; therefore,
it needs to be further studied before going into clinical trials.
Funder
Ministry of Education of China
Innovation Project of Guangxi Graduate Education
NNSF of Guangxi of China
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology,Molecular Medicine,Drug Discovery,Biochemistry,Organic Chemistry
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献