Chalcones and Bis-Chalcones Analogs as DPPH and ABTS Radical Scavengers

Author:

Bale Adebayo Tajudeen1,Salar Uzma2ORCID,Khan Khalid Mohammed1ORCID,Chigurupati Sridevi3,Fasina Tolulope4,Ali Farman1,Ali Muhammad1,Nanda Sitansu Sekhar5,Taha Muhammad6,Perveen Shahnaz7

Affiliation:

1. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

2. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

3. Department of Medicinal Chemistry and Pharmacognosy, Collage of Pharmacy, Qassim University, Buraidah 52571, Saudi Arabia

4. Department of Chemistry, University of Lagos, Lagos, Nigeria

5. Department of Chemistry, Myongji University, Yongin, South Korea

6. Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia

7. PCSIR, Laboratories Complex, Shahrah-e-Dr. Salimuzzaman, Karachi-75280, Pakistan

Abstract

Background: A number of synthetic scaffolds, along with natural products, have been identified as potent antioxidants. The present study deals with the evaluation of varyingly substituted, medicinally distinct class of compounds “chalcones and bis-chalcones” for their antioxidant potential. Methods: In vitro radical scavenging activities were performed on a series of synthetic chalcones 1- 13 and bis-chalcones 14-18. Results: All molecules 1-18 revealed a pronounced 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ- azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals scavenging potential in the ranges of IC50s = 0.58 ± 0.14 - 1.72 ± 0.03 and 0.49 ± 0.3 - 1.48 ± 0.06 μM, respectively. Ascorbic acid (IC50s = 0.5 ± 0.1 and 0.46 ± 0.17 μM for DPPH and ABTS, respectively) was used as a standard radical scavenger. Conclusion: Structure-activity relationship (SAR) revealed an active participation of various groups, including -SMe and -OMe in scavenging activity.

Funder

NAM Samp;T

Pakistan Academy of Sciences

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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