Synthesis, Nematicidal Activity and Docking Study of Novel Pyrazole-4-Carboxamide Derivatives Against Meloidogyne incognita
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Published:2018-11-01
Issue:1
Volume:16
Page:29-35
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ISSN:1570-1808
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Container-title:Letters in Drug Design & Discovery
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language:en
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Short-container-title:LDDD
Author:
Cheng Long1, Zhao Wen1, Shen Zhong-Hua1, Xu Tian-Ming2, Wu Hong-Ke1, Peng Wei-Li2, Liu Xing-Hai1
Affiliation:
1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China 2. Zhejiang Base of National Southern Pesticide Research Centre, Zhejiang Research Institute of Chemical Industry, Hangzhou 310023, China
Abstract
Background:A series of novel 2,6-dichloro-4-(trifluoromethyl)phenyl)-3-(difluoromethyl)- 1H-pyrazole-4-carboxamide derivatives were designed and synthesized.Methods:All the title compounds were confirmed by 1H NMR and MS.Results and Conclusion:The primarily nematicidal activity results indicated that some of them exhibited moderate control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita.
Funder
Research Institute Special Program of Department of Science and Technology of Zhejiang Province Zhejiang Provincial Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
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