Affiliation:
1. Department of Vascular Surgery, Tianjin Nankai Hospital, Tianjin, 300100, China
2. Department of Vascular Surgery,
Tianjin Fourth Central Hospital, Tianjin, China
Abstract
Objective:
This study used network pharmacology and molecular docking technology to explore
the molecular mechanism of Panax notoginseng in the treatment of disseminated intravascular coagulation.
Methods:
The main active components and targets of Panax notoginseng were screened by the TCMSP
database, and DIC-related targets were obtained from the GeneCards database. PPI network was constructed
by String and Cytoscape, GO gene analysis and KEGG pathway enrichment analysis were performed
by DAVID, and molecular docking was performed by AutoDock software.
Results:
Eight active compounds and 51 potential therapeutic targets of Sanqi were screened. The key targets include VEGF, MAPK3, EGFR, STAT3 and so on. Beta-sitosterol, Stigmasterol, quercetin, DFV, and Diop were identified as potential candidate ingredients. There are 95 KEGG enrichment pathways. The metabolic pathways involving a large number of genes mainly include PI3K-Akt signaling pathway, Rap1 signaling pathway, VEGF signaling pathway and TNF signaling pathway.
Conclusion:
Eight active compounds and 51 potential therapeutic targets of Sanqi were screened. The key
targets include VEGF, MAPK3, EGFR, STAT3 and so on. Beta-sitosterol, Stigmasterol, quercetin, DFV,
and Diop were identified aspotential candidate ingredients. There are 95 KEGG enrichment pathways.
The metabolic pathways involving a large number of genes mainly include the PI3K-Akt signaling pathway,
Rap1 signaling pathway, VEGF signaling pathway and TNF signaling pathway.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine