Phytochemical Characterization and Screening of the Anti-Pneumonia (Anti-COVID-19, Anti-Fungal, and Anti-Bacterial) Activities of Cuscuta Campestris Extract

Author:

Nabiabad Haidar Saify1ORCID,Amini Massoume1,Demirdas Serwet2

Affiliation:

1. Department of Biotechnology, Bu-Ali Sina University, Hamadan, Iran

2. Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, the Netherlands

Abstract

Introduction: Although several vaccines are being approved, no effective antiviral has been developed for Covid-19 infectious. The present investigation was aimed to increase the essential oils of Cuscuta campestris using far-red light treatment and examine the potential of crude extracts of C. campestris against selected pneumonia pathogens and covid-19. Methods: Anti-Covid-19 activity was determined in human lung cell lines and Covid-19 positive patients. Results: Results demonstrated that the aqueous extract had the highest amount of anti-Covid-19, antibiotic and antioxidant activity. The far-red light treatment increased Scoparone, cineole, Benzofuran, 2, 3-dihydro, Cinnamic acid, and Benzo[h]quinoline, 2, 4-dimethyl, which are mainly effective components against Covid-19 inflammation and pneumonia microbes. CT scan and clinical laboratory tests in a clinical case study, a 30-year-old woman who presented with severe 2019-nCoV, demonstrated that inhalation of 30 mg extract nebulized/day for seven days resulted in an improvement in consolidation and ground-glass opacity in lungs on the seventh day of treatment. Conclusion: It is hoped that this study would be led to the introduction of some compounds that could be used to formulate new and more potent anti-Covid-19 antibiotics, or other drugs of natural origin in medicine.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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