Affiliation:
1. Noida Institute of Engineering and Technology (Pharmacy Institute), 19 Knowledge Park -II Institutional Area, Greater
Noida, Uttar Pradesh 201306, India
Abstract
Background:
Even with the massive increase in financial investments in pharmaceutical research
over the last decade, the number of new drugs approved has plummeted. As a result, finding new
uses for approved pharmaceuticals has become a prominent alternative approach for the pharmaceutical
industry.
Objective:
Drug repurposing or repositioning is a game-changing development in the field of drug research
that entails discovering additional uses for previously approved drugs.
Methods:
In comparison to traditional drug discovery methods, drug repositioning enhances the preclinical
steps of creating innovative medications by reducing the cost and time of the process. Drug repositioning
depends heavily on available drug-disease data, so the fast development of available data as well as
developed computing skills has resulted in the boosting of various new drug repositioning methods. The
main goal of this article is to describe these different methods and approaches for drug repurposing.
Results:
The article describes the basic concept of drug repurposing, its significance in discovering new
medications for various disorders, drug repurposing approaches such as computational and experimental
approaches, and previous as well as recent applications of drug repurposing in diseases such as cancer,
COVID-19, and orphan diseases.
Conclusion:
The review also addresses obstacles in drug development using drug repurposing strategies,
such as a lack of financing and regulatory concerns and concludes with outlining recommendations for
overcoming these challenges.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference112 articles.
1. Eisenstein E.L.; Lemons P.W.; Tardiff B.E.; Schulman K.A.; Jolly M.K.; Califf R.M.; Reducing the costs of phase III cardiovascular clinical trials. Am Heart J 2005,149(3),482-488
2. Sertkaya A.; Birkenbach A.; Berlind A.; Eyraud J.; Examination of clinical trial costs and barriers for drug development. US Department of Health and Human Services, ASPE. 2014,1-92
3. Yeu Y.; Yoon Y.; Park S.; Protein localization vector propagation: A method for improving the accuracy of drug repositioning. Mol Biosyst 2015,11(7),2096-2102
4. Law G.L.; Tisoncik-Go J.; Korth M.J.; Katze M.G.; Drug repurposing: A better approach for infectious disease drug discovery? Curr Opin Immunol 2013,25(5),588-592
5. Xue H.; Li J.; Xie H.; Wang Y.; Review of drug repositioning approaches and resources. Int J Biol Sci 2018,14(10),1232-1244
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