An Insight into the Role of Biodegradable Controlled-release Polymers and Nanoformulations for Enhanced Brain Drug Delivery

Abstract

Abstract: Neurological or brain disorders are increasingly recognized as major causes of death and disability worldwide, eventually leading to the burden of non-communicable and communicable diseases in the world. Biodegradable functions of polymers provide promising solutions to meet the therapeutic needs of neurological disorders owing to advantages such as the usage of biodegradable polymers in drug delivery approaches, which has become noticeable due to their biocompatibility and degradability properties. Due to such properties, they are degraded inside the body to produce natural/ nontoxic byproducts such as water and carbon dioxide and hence eliminated easily. Sustained drug delivery by biodegradable polymer devices can increase the therapeutic efficacy of drugs by producing high local tissue concentrations over extended periods of time. This review discusses recent progress in the research and development of biodegradable polymers, including their nanoformulation approaches.