Affinity Prediction of Shikonins Towards Sirtuins and the Requisite Structural Motifs for the Selective Inhibition of SIRT2 and SIRT3
Author:
Affiliation:
1. Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2. Razi Drug Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract
Funder
research council of Mazandaran University of Medical Sciences, Sari, Iran
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Reference25 articles.
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3. Yeh YC; Liu TJ; Lai HC; Shikonin induces apoptosis, necrosis, and premature senescence of human A549 lung cancer cells through upregulation of p53 expression. Evidence-based Complement Altern Med 2015,2015
4. Wang F.; Mayca Pozo F.; Tian D.; Geng X.; Yao X.; Zhang Y.; Shikonin inhibits cancer through P21 upregulation and apoptosis induction. Front Pharmacol 2020,11(June),1-12
5. Li W.; Liu J.; Jackson K.; Shi R.; Zhao Y.; Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells. PLoS One 2014,9(4),e94079
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