5-Nitrofuran-2-yl Thiohydrazones as Double Antibacterial Agents Synthesis and In Vitro Evaluation-Reference-Cited by-同舟云学术

5-Nitrofuran-2-yl Thiohydrazones as Double Antibacterial Agents Synthesis and In Vitro Evaluation

Published:2020-03-27 Issue:3 Volume:17 Page:356-361
ISSN:1570-1808
Container-title:Letters in Drug Design & Discovery
language:en
Short-container-title:LDDD

Author:

Lukin Alexey Yurjevich¹,Vedekhina Tatiana Sergeevna¹,Chudinov Mikhail Vassiljevich¹

Affiliation:

1. Biotechnology and Industrial Pharmacy Department, Lomonosov Institute of Fine Chemical Tehnologies, MIREARussian Technological University, Vernadskogo Pr. 78, 119454, Moscow, Russian Federation

Abstract

Background: Applying of "double-drug" strategy to 5-nitrofuran derivatives has been proposed. Methods: A small library of 5-Nitrofuran-2-yl Thiohydrazones was developed, and initial screening demonstrated good activity against bacteria and fungi of ESKAPE panel. Results and Conclusion: The synthesis of the desired thiohydrazones was carried out via condensation of 5-nitrofuran-2-carbaldehyde with thiohydrazides of substituted oxamic acids.

Funder

Russian Science Foundation

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Reference22 articles.

1. Dann O.; Möller E.F.; Bakteriostatish wirkende nitroverbindunges des thiophens und furans. Chem Ber 1947,80,23-36

2. Chamberlain R.E.; Chemotherapeutic properties of prominent nitrofurans. J Antimicrob Ther 1976,2(4),325-336

3. Monasterios M.; Escorche M.; Avendaño M.; Conformational analysis, electronic properties and molecular electrostatic potential of nitrofurans derivatives with antibacterial activity. J Mol Struct 2005,748(1-3),49-55

4. Krasavin M.; Parchinsky V.; Kantin G.; Manicheva O.; Dogonadze M.; Vinogradova T.; Karge B.; Brönstrup M.; New nitrofurans amenable by isocyanide multicomponent chemistry are active against multidrug-resistant and poly-resistant Mycobacterium tuberculosis. Bioorg Med Chem 2017,25(6),1867-1874

5. Zorzi R.R.; Jorge S.D.; Palace-Berl F.; Pasqualoto K.F.M.; Bortolozzo L.S.; Siqueira A.M.C.; Tavares L.C.; Exploring 5-nitrofuran derivatives against nosocomial pathogens: Synthesis, antimicrobial activity and chemometric analysis. Bioorg Med Chem 2014,22,2844-2854

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