Affiliation:
1. Department of Pharmaceutical Sciences, PSIT-Pranveer Singh Institute of Technology Pharmacy, Kalpi Road, Bhauti,
Kanpur, 208020, Uttar Pradesh, India
2. Department of Pharmacy, University Institute of Pharmacy, Chhatrapati Shahu
Ji Maharaj University (Formerly Kanpur University), Kanpur, 208024, Uttar Pradesh, India
Abstract
Abstract:
Computer-based modelling and simulation are developing as effective tools for supplementing
biological data processing and interpretation. It helps to accelerate the creation of dosage
forms at a lower cost and with the less human effort required to conduct the work. This paper
aims to provide a comprehensive description of the different computer simulation models for various
drugs along with their outcomes. The data used are taken from different sources, including review
papers from Science Direct, Elsevier, NCBI, and Web of Science from 1995-2020. Keywords
like - pharmacokinetic, pharmacodynamics, computer simulation, whole-cell model, and cell simulation,
were used for the search process. The use of computer simulation helps speed up the creation of
new dosage forms at a lower cost and less human effort required to complete the work. It is also
widely used as a technique for researching the structure and dynamics of lipids and proteins found in
membranes. It also facilitates both the diagnosis and prevention of illness. Conventional data analysis
methods cannot assess and comprehend the huge amount, size, and complexity of data collected by
in vitro, in vivo, and ex vivo experiments. As a result, numerous in silico computational e-resources,
databases, and simulation software are employed to determine pharmacokinetic (PK) and pharmacodynamic
(PD) parameters for illness management. These techniques aid in the provision of multiscale
representations of biological processes, beginning with proteins and genes and progressing
through cells, isolated tissues and organs, and the whole organism.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Molecular Medicine,General Medicine