Affiliation:
1. General Clinical Research Center, Ordos Central Hospital, Ordos School of Clinical Medicine, Inner Mongolia Medical
University, Ordos 017000, China
2. State Key Laboratory of Metastable Materials Science and Technology, College
of Material Science and Engineering, Yanshan University, Qinhuangdao 066004, Hebei, China
3. Department of Chemical
Engineering, Ordos Institute of Technology, 017000, Ordos, China
Abstract
Background:
PPAR-γ is one of three members of the PPAR group of the nuclear receptor
superfamily and plays an important regulatory role as a ligand-dependent transcription factor.
Objective:
This study aimed to identify the top 100 most influential articles in the field of
PPAR-γ. We hypothesized that a bibliometric and scientometric analysis of the PPAR-γ research
field could render trends that provide researchers and funding agencies valuable insight
into the history of the field, and potential future directions.
Methods:
A literature search of publications was carried out using the Web of Science (WOS) and
Scopus database based on specific subject words on September 11, 2023. Articles were listed in
descending order of the number of citations. Statistical analysis was performed on the data of the
top 100 cited articles in terms of year of publication, journal, research direction, institution, author,
and country. Meanwhile, co-authorship networks and co-citation networks were constructed by
using VOSviewer software, and keywords were analyzed for co-occurrence.
Results:
A total of 9,456 articles regarding PPAR-γ were identified and analyzed based on the
WOS database, and the top 100 cited articles in the field of PPAR-γ were ranked by citation.
The most cited article was published in 1998, with 2,571 citations and a density of 102.80 citations/
year. Of the 100 articles, Harvard University was the institution with the highest number
of articles published. Spiegelman, B. M. was the author with the highest number of articles published.
Using the VOSviewer software, we found that the most used keywords were geneexpression,
activated receptor-gamma, and adipocyte differentiation. PPAR-γ, one of the most
widely studied transcription factors, is an important drug target for many diseases. Therefore,
screening for small molecule compounds targeting PPAR-γ remains of great value.
Conclusion:
The present study identified the top 100 most influential articles in the field of
PPAR-γ, which help global researchers to better understand research perspectives and develop
future research directions of PPAR-γ.
Publisher
Bentham Science Publishers Ltd.