Circulating and Tissue microRNAs as Biomarkers for Ovarian Cancer Prognosis

Author:

Parizadeh Seyed Mostafa1,Jafarzadeh-Esfehani Reza2,Ghandehari Maryam1,Hasanzadeh Malihe3,Parizadeh Seyed Mohammad Reza1,Hassanian Seyed Mahdi1,Rezaei-Kalat Afsaneh4,Aghabozorgi Amirsaeed Sabeti5,Rahimi-Kakhki Rana1,Zargaran Bita1,Ferns Gordon A6,Avan Amir1

Affiliation:

1. Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran

2. Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3. Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4. Department of Psychiatry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

5. Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

6. Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, United Kingdom

Abstract

Ovarian cancer (OC) is one of the most common cancers globally with a high rate of cancer- associated mortality. OC may be classified into epithelial cell neoplasms, germ cell neoplasms and stromal cell neoplasms. The five-year survival in the early and advanced stages of disease is approximately 90% and 15%, respectively. microRNAs are short, single-stranded, non-coding ribonucleic acid (RNA). miRNAs play critical roles in post transcriptionally regulations of gene expression. miRNAs are found in different tissues and body fluids. In carcinogenesis the expression of miRNAs are altered. Recent studies have revealed that there is a relationship between alteration of miRNAs expression and the prognosis of patients with OC. The aim of this review was to summarize the findings of recent studies that have investigated the expression of circulating and tissue miRNAs as novel biomarkers in the prognosis of OC.

Publisher

Bentham Science Publishers Ltd.

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine

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