The Potential of Mur Enzymes as Targets for Antimicrobial Drug Discovery-Reference-Cited by-同舟云学术

The Potential of Mur Enzymes as Targets for Antimicrobial Drug Discovery

Published:2023-08-03 Issue:8 Volume:24 Page:627-647
ISSN:1389-4501
Container-title:Current Drug Targets
language:en
Short-container-title:CDT

Author:

Kumar Dharmendra¹,Sarkar Nandan²,Roy Kuldeep K.³,Bisht Dheeraj⁴⁵,Kumar Deepak⁶,Mandal Bitasta²,Rajagopal Mogana⁷,Dey Yadu Nandan⁸^ORCID

Affiliation:

1. Narayan Institute of Pharmacy, Gopal Narayan Singh University, Jamuhar, 821305, Bihar, India

2. Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Barasat, Kolkata, 700126, India

3. Department of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES, Dehradun, 248007, Uttarakhand, India

4. Department of Pharmaceutical Sciences Bhimtal Campus, Kumaun University, Nainital, 263136, Uttarakhand, India

5. Devsthali Vidyapeeth College of Pharmacy Rudrapur, 263148, Uttarakhand, India

6. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University Solan, 173229, Himachal Pradesh, India

7. Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur, 56000, Malaysia

8. Department of Pharmacology, Dr. B.C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, 713206, West Bengal, India

Abstract

Abstract: The extensive development in the strains of resistant bacteria is a potential hazard to public health worldwide. This necessitates the development of newer agents with the antibacterial property having new mechanisms of action. Mur enzymes catalyze the steps related to the biosynthesis of peptidoglycan, which constitutes a major part of the cell wall in bacteria. Peptidoglycan increases the stiffness of the cell wall, helping it to survive in unfavorable conditions. Therefore, the inhibition of Mur enzymes may lead to novel antibacterial agents that may help in controlling or overcoming bacterial resistance. Mur enzymes are classified into MurA, MurB, MurC, MurD, MurE, and MurF. Until-date, multiple inhibitors are reported for each class of the Mur enzymes. In this review, we have summarized the development of Mur enzyme inhibitors as antibacterial agents in the last few decades.

Funder

Science and Engineering Board (SERB), the Department of Science and Technology, New Delhi, India

Publisher

Bentham Science Publishers Ltd.

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Medicine

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