The Potential Value of Sputum Level Interleukin38 and NLRP3 Inflammasome in Severe Childhood Asthma-Reference-Cited by-同舟云学术

The Potential Value of Sputum Level Interleukin38 and NLRP3 Inflammasome in Severe Childhood Asthma

Published:2024-04-02 Issue: Volume: Page:159-181
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Container-title:The NLRP3 Inflammasome: An Attentive Arbiter of Inflammatory Response
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Author:

Hamzaoui Agnès¹,Louhaichi Sabrine¹,Hamzaoui Kamel¹

Affiliation:

1. Tunis El Manar University, Medicine Faculty of Tunis, Department of Paediatric and Respiratory Diseases, Abderrahman Mami Hospital, Pavillon B, Ariana, Research Laboratory 19SP02 “Chronic Pulmonary Pathologies: From Genome to Management”, Tunisia

Abstract

Asthma in children is associated with serious exacerbations that are modulated by inflammation. The expression of inflammatory cytokines varies according to the severity of the disease. The transition from the state of exacerbation of the disease to the state of cure always passes through a relationship between inflammatory and anti-inflammatory mediators. This study looks at the expression of IL-38 and NLRP3 inflammasome in severe childhood asthma. NLRP3 inflammasome is upregulated in severe asthma, contrasting with low levels of IL-38. The inflammatory pattern of severe asthma in children is characterized by the expression of IL-17, IL-32, IL-1β, and NLRP3 inflammasome.

Publisher

BENTHAM SCIENCE PUBLISHERS

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