Comprehensive Insights into Mucoadhesive Drug Delivery Systems

Abstract

Mucoadhesive drug delivery systems have gained significant attention in the field of pharmaceutical research due to their ability to enhance drug bioavailability, prolong residence time, and improve therapeutic outcomes. This chapter provides a comprehensive overview of mucoadhesive drug delivery systems, highlighting their importance in overcoming various challenges associated with conventional drug delivery. The chapter commences by elucidating the physiological and biochemical aspects of mucosal surfaces, emphasizing the significance of mucoadhesion in optimizing drug absorption and distribution. It explores the diverse applications of mucoadhesive systems across different mucosal sites, including the buccal, nasal, ocular, vaginal, and gastrointestinal mucosa. Additionally, the mechanisms underlying mucoadhesion, such as hydrogen bonding, electrostatic interactions, and covalent bonding, are thoroughly examined. The chapter delves into the various classes of mucoadhesive polymers, such as natural, synthetic, and semi-synthetic polymers, highlighting their distinct properties, applications, and evaluations. The chapter addresses key considerations such as biocompatibility, safety, and regulatory aspects associated with the development of mucoadhesive formulations. In conclusion, this chapter serves as a valuable resource for researchers, scientists, and practitioners in the field of drug delivery, offering a comprehensive understanding of mucoadhesive drug delivery systems and their potential to revolutionize the delivery of therapeutic agents across mucosal membranes.