Affiliation:
1. Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, School of Chemistry &
Chemical Engineering, Harbin Normal University, Harbin, 150025, China
Abstract
Abstract:
Chemotherapy is one of the most important treatment modalities for liver cancer, especially
for those who are judged as being unsuitable for surgical resection, local ablative therapy, or
transarterial chemoembolization. However, the efficacy of chemotherapy is still unsatisfactory due to
the long duration, side effects and the tendency to develop drug resistance. The development of novel
anti-liver cancer drugs remains imperative. Cyclopeptides have been recognized as new chemical
modalities in drug design due to their unique constrained structures, extensive biological activities,
higher metabolic stability, cell permeability and bioavailability than linear peptides. A lot of cyclic
peptides have been found with potential anti-proliferative activity against malignant cells, and many of
them showed excellent anti-liver cancer activity. In this review, we will discuss in detail the structures
and the anti-liver cancer activity of small and medium-sized cyclopeptides, aiming to offer some
elicitation to chemotherapeutic drug design based on cyclopeptides.
Funder
Joint Foundation of Natural Science Foundation Heilongjiang Province of China
Graduate Innovation Projects of Harbin Normal University
College Students Innovation and Entrepreneurship Training Program of Heilongjiang Province
Publisher
Bentham Science Publishers Ltd.
Subject
Biochemistry,General Medicine,Structural Biology