Affiliation:
1. Department of Cardiology and The First Affiliated Hospital of Jinan University, Guangzhou, China
2. The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China
Abstract
Background:
Myocardial metabolism is closely related to functional changes after myocardial
infarction (MI).
Objective:
This study aimed to present an integrative examination of human ischemic cardiomyopathy.
Methods:
We used both GSE121893 single-cell suspension sequencing and GSE19303 transcription
microarray data sets from the GEO database, along with a murine MI model for full-spectrum metabolite
detection. Through a systematic investigation that involved differential metabolite identification
and functional enrichment analysis, we shed light on the pivotal role of energy metabolism dysregulation
in the progression of MI.
Results:
Our findings revealed an association between the core regulatory genes CDKN1A, FOS,
ITGB4, and MAP2K1 and the underlying pathophysiology of the disease. These genes are identified
as critical elements in the complex landscape of myocardial ischemic disorder, highlighting novel
insights into therapeutic targets and the intricate biological mechanisms involved.
Conclusion:
This analysis provides a framework for future research on the metabolic alterations associated
with MI.
Publisher
Bentham Science Publishers Ltd.