Affiliation:
1. National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese
Medical Sciences, Beijing, China
2. Second Department of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China
Abstract
Objective:
To investigate the current status and development trend of research on exosomes
in cardiovascular disease (CVD) using bibliometric analysis and to elucidate trending research topics.
Methods:
Research articles on exosomes in CVD published up to April 2022 were retrieved from the
Web of Science database. Data were organized using Microsoft Office Excel 2019. CiteSpace 6.1 and
VOSviewer 1.6.18 were used for bibliometric analysis and result visualization.
Results:
Overall, 256 original research publications containing 190 fundamental research publications
and 66 clinical research publications were included. "Extracellular vesicle" was the most frequent
research keyword, followed by "microrna," "apoptosis," and "angiogenesis." Most publications
were from China (187, 73.05%), followed by the United States (57, 22.27%), the United Kingdom (7,
2.73%), and Japan (7, 2.73%). A systematic review of the publications revealed that myocardial infarction
and stroke were the most popular topics and that exosomes and their contents, such as microRNAs
(miRNAs), play positive roles in neuroprotection, inhibition of autophagy and apoptosis,
promotion of angiogenesis, and protection of cardiomyocytes.
Conclusion:
Research on exosomes in CVD has attracted considerable attention, with China having
the most published studies. Fundamental research has focused on CVD pathogenesis; exosomes regulate
the progression of CVD through biological processes, such as the inflammatory response, autophagy,
and apoptosis. Clinical research has focused on biomarkers for CVD; studies on using
miRNAs in exosomes as disease markers for diagnosis could become a future trend.
Funder
Fundamental Research Funds for the Central public welfare research institutes
Publisher
Bentham Science Publishers Ltd.
Subject
Cardiology and Cardiovascular Medicine,Pharmacology