GDF-10 Induces an Inhibitory Effect on Epithelial-Mesenchymal Transition of Laryngeal Cancer via LPR4-Reference-Cited by-同舟云学术

GDF-10 Induces an Inhibitory Effect on Epithelial-Mesenchymal Transition of Laryngeal Cancer via LPR4

Published:2023-12 Issue:43 Volume:29 Page:3467-3477
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Kan Xuan¹^ORCID,Ai Li²,Guan Ruidi¹,Hao Jianwei¹,Sun Yanan¹,Xiu Wei³

Affiliation:

1. Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China

2. The Second Operating Room, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

3. Department of Pharmacy, Heilongjiang Forest Industry General Hospital, Harbin 150040, China

Abstract

Background: Growth differentiation factor-10 (GDF-10), a member of the TGF-β superfamily, plays a crucial role in cell proliferation and differentiation. In some tumors, GDF-10 can act as a tumor suppressor to inhibit tumor progression, but its role in posterior squamous cell carcinoma has not been reported yet. Methods: The aim of this study was to investigate the effect of GDF-10 on the epithelial-mesenchymal transition of laryngeal squamous cell carcinoma, and to provide new ideas for future targets in the treatment of laryngeal squamous carcinoma. Results: The effect of GDF-10 on tumor growth was detected; bioinformatics analysis was performed to predict the downstream targets of GDF-10, and RT-PCR and western blot were performed to detect the expression levels of target genes and proteins, respectively. Conclusion: Our findings support that GDF-10 can inhibit the proliferation, migration, and invasion, and promote apoptosis of laryngeal carcinoma AMC-HN-8 cells. GDF-10 inhibits the EMT of laryngeal carcinoma through LRP4 and thus inhibits the progression of laryngeal carcinoma.

Funder

Project of Heilongjiang Postdoctoral Foundation

Young and Innovative Science Research Foundation of Second Affiliated Hospital of Harbin Medical University

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,Pharmacology

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