Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights-Reference-Cited by-同舟云学术

Colorectal Cancer Stem Cell Biomarkers: Biological Traits and Prognostic Insights

Published:2024-05 Issue:18 Volume:30 Page:1386-1397
ISSN:1381-6128
Container-title:Current Pharmaceutical Design
language:en
Short-container-title:CPD

Author:

Soleimani Atena¹,Saeedi Nikoo²,Al-Asady Abdulridha Mohammed³,Nazari Elnaz⁴,Hanaie Reyhane⁵,Khazaei Majid⁴,Ghorbani Elnaz⁶,Akbarzade Hamed¹,Ryzhikov Mikhail⁷,Avan Amir⁸,Mehr Seyed Mahdi Hasanian¹

Affiliation:

1. Department of Biochemistry, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran

2. Medical School, Islamic Azad University, Mashhad, Iran

3. Department of Pharmacology, University of Warith Al-Anbiyaa, Karbala, Iraq

4. Department of Physiology, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran

5. Department of Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran

6. Department of Microbiology, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran

7. Department of Biochemistry, Saint Louis University, St. Louis, MO 63103, USA

8. Department of Genetics, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran

Abstract

Abstract: Due to self-renewal, differentiation, and limitless proliferation properties, Cancer Stem Cells (CSCs) increase the probability of tumor development. These cells are identified by using CSC markers, which are highly expressed proteins on the cell surface of CSCs. Recently, the therapeutic application of CSCs as novel biomarkers improved both the prognosis and diagnosis outcome of colorectal Cancer. In the present review, we focused on a specific panel of colorectal CSC markers, including LGR5, ALDH, CD166, CD133, and CD44, which offers a targeted and comprehensive analysis of their functions. The selection criteria for these markersCancer were based on their established significance in Colorectal Cancer (CRC) pathogenesis and clinical outcomes, providing novel insights into the CSC biology of CRC. Through this approach, we aim to elevate understanding and stimulate further research for developing effective diagnostic and therapeutic strategies in CRC.

Publisher

Bentham Science Publishers Ltd.

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