Affiliation:
1. Bharath Institute of Higher Education and Research, Chrompet, Chennai, India
2. School of Pharmaceutical Sciences,
Lovely Professional University, Phagwara, Punjab, India
3. KIET School of Pharmacy, KIET Group of Institutions,
Delhi-NCR, Ghaziabad, Uttar Pradesh, India
Abstract
Abstract:
Secondary metabolites of natural origin exhibit numerous pharmacological activities, like
anti-inflammatory and anti-oxidant effects. Lipid peroxidation has been observed to be prevented by
terminating free radical chains and chelating redox active metal ions. These properties of the secondary
products can also aid in preventing carcinoma. Many traditional and emerging plants are blessed
with plenty of unexplored phytometabolites, which contain the probability to carry huge antineoplastic
potential. Acetogenins are anticancer compounds that kill tumor cells through a variety and
series of developmental methods. They are very powerful apoptosis inducers that can regulate the exclusion
of chemotherapy medicines from cancer cells. Chalcone is a pharmacologically active molecule
that can be found in both natural and manufactured products. Marine species, which are also examples
of naturally derived drug sources, such as algae, sponges, tunicates, and bryozoans, have
emerged as important components of choice for the separation of novel anticancer drugs obtained
from marine sources. Bacteria of marine origin are the source of new drug discoveries and therapeutic
targets, which are being explored to unprecedented heights, and they have proven to be sources of various
medicinal agents, such as antibiotics, etc. Numerous secondary metabolites have been isolated
from marine fungi that were active biologically, structurally unique, and also therapeutically beneficial.
So far, almost 1000 secondary metabolites have been found, the majority of which are exclusive
to lichens. This mini-review discusses different aspects related to the natural derivatives obtained from
various sources, which play a pivotal role as anti-neoplastic agents.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
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