Affiliation:
1. Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, 31982, Saudi Arabia
2. Department of
Polymer Science & Engineering, University of Southern Mississippi, Hattiesburg, Mississippi, 39406, United States
3. Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-suef, 62514, Egypt
Abstract
Abstract:
This review covers the literature information on the chemistry of hydrazonoyl halides with
different substrates to give heterocyclic compounds. From the foregoing survey, it seems this provides
a useful and convenient strategy for the synthesis of numerous heterocyclic derivatives. The subject of
such reactions is still ongoing and undoubtedly will provide new fused functionalized compounds of
both industrial and biological interest. A literature survey revealed that a great deal of interest has been
focused on the synthesis of functionalized heterocyclic compounds due to their wide range of biological
activities, such as contact dermatitis, anthelmintic, antiviral, antimicrobial, herbicidal, and anti-cancer.
On the other hand, hydrazonoyl halides are interesting synthons for valuable bioactive heterocyclic
compounds. The reaction of hydrazonoyl halides with various types of substrates gave a huge number
of different heterocyclic systems. In this review, we collected all reactions of hydrazonoyl halides with
different moieties and classified them as aryl diazo of monoheterocycles, aryldiazo of 5,5-bis-heterocycles,
aryldiazo of 5,6-bis-heterocycles, aryldiazo of 6,6-bis-heterocycles, aryldiazo of 5,5,6-tri-heterocycles,
aryldiazo of 5,6,6-tri-heterocycles, aryldiazo of 6,6,6-tri-heterocycles, hetero annulation of bisheterocycles,
hetero annulation of tri-heterocycles, hetero-annulation of tetra-heterocycles, synthesis of
spiro-heterocycles, heterocyclic ring transformations, and 1,3-dipolar cycloaddition reactions catalyzed
by transition metals using hydrazonoyl halides as substrates.Most reaction types have been successfully
applied and used in the production of biologically active compounds.
:
The aim of the present survey is to consider in the reader the opportunity interactions and biological
activities of hydrazonoyl halides. The information of several artificial paths and varied physics-chemical
factors of such heterocycles made a special consideration of chemists in different fields to yield
a combinatorial library and carry out thorough efforts in the search for hydrazonoyl halides.
Funder
Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia
Publisher
Bentham Science Publishers Ltd.